Molecular engineers have developed an incredibly small mechanism similar to molecular robots that can move and work in agreement. The project, led by Peter Schulz from the University of Arizona, Michael Famulok from the University of Bonn, and Nils Walter from the University of Michigan, has resulted in the creation of a DNA-sized mechanism measuring 70 nm × 70 nm × 12 nm. This groundbreaking achievement utilizes chemical energy to generate controlled rhythmic movement, showcasing the potential for accurate nanoscale devices in various fields including nanotechnology, medicine, and materials science.
Comprising nearly 14,000 nucleotides, which are basic structural units of DNA, the nano-engine’s structure was simulated using the computer model Oxdna. Schulz emphasized that without this model, simulating the movement of such a large nanostructure would have been impossible. “This is the first time we managed to create a chemically activated DNA-based engine. We are looking forward to creating even more complex nanomachines in the future,” he said.
The nano-engine’s mechanism operates on a principle similar to a vise, but on a million times smaller scale. It consists of two handles connected by a V-shaped spring, allowing scientists to control the device by squeezing the handles against the resistance of the spring. Schulz likened the process to playing with LEGO blocks, with each block measuring only a few nanometers. This technology holds promise for applications in diagnosis, therapy, molecular robotics, and the development of new materials.
The findings of the study were published on October 19 in the journal Nature Nanotechnology.