Scientists of the University of Washington have achieved a breakthrough in studying human aging at the cellular level. Led by Professor Ziyue Zhu, the research group developed genetically modified mice with shortened telomeres – protective caps at the ends of chromosomes that prevent their degradation, similar to the tips on shoelaces.
Typically, telomeres in mice are ten times longer than those in humans, making it challenging to study the aging process in these animals. The new mouse model, named Hut (Humanized Telomeres), allows researchers to investigate aging in a system that closely resembles the human condition.
The team intends to use these mice to explore the impact of short telomeres on cancer development and lifespan. Their focus is on finding ways to extend the period of healthy life, free from age-related ailments.
Professor Zhu emphasizes that many diseases have their origins at the cellular level. Thus, developing medications that protect telomeres could be crucial in combating aging and increasing longevity.
Additionally, the research group is investigating the role of telomerase, an enzyme essential for rapid cell division in cancer cells. Inhibiting telomerase activity in cancer cells is a promising approach in fighting against cancer.
The HUT-Mosh model presents new avenues for research. A team led by Christopher Davis from Elson Medical College S. Floyd aims to study the influence of sleep disturbances and other stress factors on telomere regulation and aging processes.
The development of the HUT-MOSE model started a decade ago, driven by a better understanding of telomere regulation mechanisms in humans. Previously, research was limited to isolated human cells in laboratory settings.
Professor Zhu highlights the similarities between these mice and humans in terms of organ structure, genes, and genetic makeup. The research team intends to share the HUT-Mysers model with other scientific groups to advance the study of aging, longevity, and cancer.