Scientists have made a groundbreaking discovery on the influence of adipose tissues on life expectancy by establishing a unique mechanism through their connection with the brain. In a series of new studies conducted on mice, it has been revealed that fatty tissues exchange signals with a group of neurons in the hypothalamus which regulate crucial bodily functions such as temperature regulation and breathing (source).
As individuals age, this connection weakens leading to a decline in the ability of fat cells to carry out various functions, as well as the impairment of information transmission by neurons. Headed by Dr. Shinitiro Imai from the University of Washington, a team of scientists has found that manipulating the behavior of the PPP1R17 protein, through genetic engineering, in aging mice leads to an increase in their life expectancy by a remarkable seven percent. This translates to an average increase in human life expectancy of over five years.
The study has also demonstrated that reactivating the connection between adipose tissues and the brain in aging mice results in a rejuvenated appearance, heightened activity levels, and improved health. These physical improvements serve as indicators of youthfulness and overall well-being.
Given the increasing relevance of scientific research exploring the connections between the brain and the body in the quest to unravel longevity mechanisms, the team of scientists continues to investigate methods to optimize the connection between adipose tissues and the brain as individuals age. These discoveries hold the potential to unlock the secret to prolonging a healthy life span in humans.