This advance carried out with a infusion system could facilitate organ transplants in humans and improve the emergency treatment of strokes and infarction.
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How, after a stroke (stroke), a heart attack or a respiratory stop, protect cells and organs from the harmful effects linked to oxygen deprivation and its reintroduction? In the
The group at the origin of this advance had already, in 2019, developed a technique called Brainex, which restored a certain degree of metabolic activity in pig’s brain cells, four to six hours after a deprivation of oxygen. However, the authors insisted, if the cells were active, the brains showed no sign of consciousness or perception. This strategy called on a specialized fluid, a cryoprotector perfusat, pumped through the blood vessels of the animal’s brain. This perfusat contained a synthetic form of hemoglobin (the protein which transports oxygen in red blood cells) as well as a cocktail of protective molecules, in particular to prevent blood clots.
In the current study, the authors optimized this fluid by adapting it to the infusion of the whole body. To test their system, they caused cardiac arrest in pigs. An hour after their death, this modified fluid was perfused using a computer controlled system that maintained the perfusat molecules at stable levels. The authors then compared the efficiency of Organnex to that of an extracorporeal respiratory assistance system, oxygenation by extracorporeal membrane (ECMO), a device used in the event of severe circulatory or respiratory failure and in patients suffering from ‘A serious form of covid-19.
Result, “After six hours of infusion, Organnex was much more effective than ECMO to circulate fluids again in the arteries and organs”, summarizes Brendan Parent. The ECMO, in fact, has not allowed a correct infusion of all the organs, many small blood vessels having sagged. “On the other hand, the Organnex system has enabled a complete reperfusion and a stable oxygen consumption,” said Robert Porte from the University of Groningue (Netherlands), in an article in perspective of the study.
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