Scientists of the Institute of Cytology of the Russian Academy of Sciences found that some aging cells are resistant to testing-sensitics and mechanisms provoking a programmable cell death. Such cells limit the effectiveness of anti-aging preparations and continue to have a harmful effect on the environment. This is reported in a press release of the study published on the SDUNUKI website.rf.
Normally aging (or sensitive) cells are destroyed by immunity, but with age or at various diseases, purification becomes less efficient. As a result, increases the risk of inflammatory reactions, as well as neurodegenerative diseases, such as Parkinson or Alzheimer’s diseases, osteoarthritis, cardiovascular disorders. It was previously believed that sensitolics block any mechanisms that increase the survival rate of the sensory cells during apoptosis (the process of programmable cell death), but a new study showed that it is not so.
Researchers conducted experiments on stem cells that can turn into various types of other cells: fat, bone, cartilage, muscle and nervous. Cultures were subjected to damaging DNA substances and hydrogen peroxide, starting the oxidative stress to simulate the aging process. After a certain time, scientists tried to kill the cells by the senolithics.
The results showed that all types of stem cells were immune to drugs. Thus, sensitolics act only on those cells that did not acquire sustainability to apoptosis. According to the authors of work, it is likely that the drugs affect the other mechanisms necessary for the survival of old cells, and not on those associated with apoptosis. To kill such cells, you need to use additional drugs.