University scientists The monastery in Australia has discovered an enzyme that plays a key role in improving health with exercises. The discovery can be the basis for drugs that contribute to the activity of the enzyme and protecting both the effects of aging and age-related diseases, for example, type 2 diabetes. This is reported in an article published in the journal Science Advances.
One of the main causes of type 2 diabetes as an age disease is the development of insulin resistance or the inability of the body to respond to insulin, which is often associated with a decrease in physical activity. The researchers disclosed that physical activity does increase the sensitivity to insulin and, in turn, contributes to healthy metabolism and disease prevention.
Reduction of the formation of active forms of oxygen (AFC) in skeletal muscles during aging contributes to the development of insulin resistance. AFC provoke adaptive reactions that are an integral part of the wellness effect of exercises. The development of active forms of oxygen is enhanced with the participation of the Enzyme NOX-4. It is shown that the NOX-4 content in skeletal muscles decreases with age, and this correlates with increasing insulin resistance.