Researchers from Japan and the United States have revealed that SARS-COV-2 may fail an important molecular path associated with the immune complex, called the main immunosomicurability complex of MNS-I. This can explain how coronavirus avoids protective systems of the body. This is reported in an article published in the Nature Communications magazine.
Scientists demonstrated as the SARS-COV-2 virus, which causes COVID-19, hacks the expression of genes in the immune system of patients. This allows you to study the function of complex cellular signaling pathways that launch immune responses to combat bacteria and viruses. The MNS-I mechanism plays one of the central roles in the immune response against viruses, allowing an infected cell to attract cytotoxic T cells.
The results showed that the SARS-COV-2 virus protein, called ORF 6, suppresses the protein of the host cell, called the NLRC5 and the responsible for activation of MNS-I. ORF6, as prevents the transmission of cellular signals, which disables the expression of the NLRC5, and directly blocks the NLRC5 function. Further research will help you find and test drugs that block the activity of the virus protein ORF6.