The elimination of old dysfunctional cells in human adipose tissue reduces the signs of the second type diabetes. The results of the study published by the University of Connecticut in the Cell Metabolism magazine will help develop new ways of treating various metabolic diseases. Briefly about scientific work is described in a press release on MedicalXpress.
In the body there is a constant updating of cells, but sometimes this mechanism refuses. As a result, aging or density cells are accumulated in tissues, which affect their surroundings, producing defective signaling molecules. As a result, the surrounding cells may be worse to absorb nutrients, such as sugar, causing prediabetic state.
Scientists have developed and tested combinations of experimental drugs: dasatinib and quercetin. It has already been shown that dasatinib and quercetin increase the life expectancy and improve health in old mice. According to the data obtained, these drugs can cope with aging cells in human adipose tissue cultures. The cells of the adipose tissue were also introduced by mice, which they caused metabolic disorders. However, after treatment with dasatinib and quercetin, the harmful effects of adipose tissue almost disappeared.
Researchers also analyzed the previously unexplored population of aging cells, which express high levels of P21 – inhibitor of cyclin-dependent kinase and one of the key markers of cell aging. It turned out that purification from deletence cells once a month is effective both to slow down the development of diabetes and to facilitate the manifested diabetic symptoms in mice with obesity.