Researchers from Australia identified in blood three products of metabolism, a change in the content of which increases the risk of migraine in humans. Dedicated to previously unknown risk factors. Article of scientists has been published in The American Journal of Human Genetics.
Specialists from Queensland Technological University conducted a complete search for associations, within which the correspondence of the level 316 is evaluated for the blood of metabolites and the risk of migraine. Of these, in 44 – mostly in lipids and organic acids – the genetic overlap with migraine was found.
However, the causal relationship was able to identify only for the three metabolic products. It turned out that the risk of migraine development increases with a reduced level of docosahexane acid (DGK) – a very long fatty acid of the Omega-3 class, which is part of the lipids of most animal tissues.
“The lower levels of DGK are associated with inflammation, violations in the work of the cardiovascular system and the brain, which are all associated with the risk of migraine,” said the head of the scientific group Dale Nichold. However, in general, people with migraine the level of fatty acids in the blood was higher. In addition, high levels of lysophosphatidallethanolamine 20: 4 – compounds blocking the production of an anti-inflammatory molecule were associated with an increased risk of migraines. Lower levels of the unknown earlier metabolite X-11315 also increased the risk of migraine