American scientists have demonstrated that the treatment of animals by a medicinal cocktail, which contributes to the removal of aging cells, reduces the degeneration of vertebral discs. The new tool against chronic back pain is reported in the article published in the Nature Communications magazine.
agent cells accumulate in each body tissue. Older cells allocate destructive enzymes and inflammatory proteins that affect nearby healthy cells. Sensolitic drugs remove these collapsing cells, leaving a place for new ones. The idea of scientists was that removal of aging cells should improve the functioning of the tissue.
At the moment, two sensing drugs, dasatinib and quercetin are fairly effective means for the treatment of scars in the pulmonary fabric, and now they pass clinical trials. To check whether sensitolics can improve the state of the vertebral discs, the scientists have gave young and elderly a cocktail of senolitic drugs.
It turned out that the treatment of younger animals gives more benefits and actually has a larger protective effect than the therapy of old mice. At the same time, the mouse of young and middle age, which received a sensing cocktail, showed less degeneration of discs and fewer aging cells by the time they have reached old age, compared with mice receiving placebo. Preparations were required to be administered periodically, but the researchers have not yet revealed any detrimental effects.