Restoration of the intestine microflora after the course of antibiotics is associated with a decrease in the life expectancy in mice, the Australian researchers found out. The work of scientists is published in the Cell Reports magazine.
B During its study, experts studied long-term effects from the introduction of mice at the early stage of the life of antibiotics. Observed experimental from the beginning of the reception of drugs – ampicillin and neomycin – up to old age (102 weeks). Antibiotics seriously reduced the variety of microbioma, after which the intestine was settled, as a rule, one of two sets of microbiota designated by researchers as Pam I and Pam II, respectively.
The mice with Pam II later there was an increased insulin resistance, which indicates disorders of metabolism and enhancing inflammation in various tissues, including in the liver and brain. They have decreased and the production of antibodies after flu vaccination. These mice died about two times faster than counterparts with PAM I – even despite the fact that in both cases the composition of the intestinal microbiome was subsequently returned to normal.
“Results [Research] It is suggested that the type of microbioma that settles the gum after [Introduction] antibiotics has the ability to reprogram the immune system of mammals with long-term consequences, including for life expectancy,” said the lead author of the study, Professor University of Flinders David Lynn.