Scientists of the Massachusetts Hospital of the General Profile, US, disclosed that the hormone irisine has the ability to stimulate cognitive functions in exercise and, therefore, potentially promising for the treatment of cognitive disorders in Alzheimer’s disease. This peptide hormone is highlighted by muscles during exercise. The results of the study are published in the journal Nature Metabolism.
Scientists have shown that in mutant mice with a dysfunctional gene encoding irisin, cognitive functions are worse with aging and alzheimer’s disease, which partly caused changes in neurons in newborns in the hippocampus. At the same time, the study demonstrated that the increase in the level of irisin in the bloodstream improves cognitive functions and protects the brain from inflammatory processes in mice modeling Alzheimer’s disease.
Inflammation of the nervous system is reduced by influencing glial cells in the brain. According to scientists, because Irizin is not aimed directly on amyloid plaques, but on the neuro-visibility, they hope that the use of hormone can be a way of treating neurodegenerative diseases, in addition to Alzheimer’s disease.