Russian scientists discovered the most dangerous strain of Mycobacterium tuberculosis of the pathogen of tuberculosis, which differs from the other options for high death. However, Beijing 14717-15 almost does not occur outside Republic of Buryatia. This is reported in a press release on the RHF website.
Beijing genotype is the most studied among all phylogenetic lines M.TUBERCULOSIS due to its widespread. Stamps related to this line are divided into two sublines: ancestral and modern. Modern sublimity is characterized by a high pathogenicity, in contrast to a low-aluminous alert and spread throughout the world. It includes the Russian strain of Beijing B0 / W148, Cao (Central Asian Outbreak), Central Asian / Russian. However, the virulence of the variants of the ancient subluna is little studied.
Researchers studied the virulence of Russian strains M.TUBERCULOSIS, belonging to the ancient subluna of Beijing. Options 6691 (1071-32) and 396 (14717-15) from Buryatia, as well as a reference strain H37RV were investigated on mice. It turned out that the Buryat version led to the death of a large number of animals, in the body of which there was a high bacterial load and significant lung pathologies. Thus, option 14717-15 The most deadly of all Russian genotypes M.TUBERCULOSIS.
High-body and hypervirulent strain Beijing 14717-15 is common in Buryatia, but only sometimes occurs beyond. This can be explained by the population features of the human immune system and the genetics of the strain.