Immunomodulators in combination with antidepressant fluoxetine are able to cope with anxiety, which can lead to dangerous mental disorders. A new way to combat stress disclosed Russian scientists with colleagues from the University of Maastricht in the Netherlands. This is reported in a press release on the SDUNUKI website.rf.
Researchers simulated long-term stress at Danio-Roerio fish, including adverse water temperature, presence of a predator or smell, bright light or darkness, as well as lack of food. As an antidepressant, scientists used the fluoxetine widely used in medicine together with lipopolysaccharide and eikapentaenoic acid, which is anti-inflammatory effect. The experiencing stress fish changed behavior: animals preferred to swim at the bottom, and also left from a usually comfortable small part of the aquarium, where electric current was served.
After the fish killed, the researchers analyzed their nervous tissues to study hormonal status. It turned out that antidepressants and immunomodulators removed stress and reduced the level of norepinephrine associated with it. The combination of fluoxetine with eico-seated acid has a strong effect, restoring the calm behavior of fish and normalizing the level of stressful hormone. Lipopolysaccharide, on the contrary, strengthened anxiety.
Scientists are planning deeper to examine the interaction of fluoxetine and eikapentaenoic acid immunomodulators and lipopolysaccharide among themselves to understand the mechanisms of strengthening or weakening their effectiveness in the fight against stress.