long-livers are less susceptible to age chronic diseases and are more likely to survive infectious diseases. As scientists of the Brodov Institute at the Massachusetts Institute of Technology and Harvard, people who live more than a hundred years have a unique microbi of them, which protects them from bacterial infections, including those that have resilience to drugs. The secret of longevity was revealed in an article published in the Nature magazine.
Researchers analyzed the microbis in Kale 160 of the Japanese-long-livers, the average age of which reached 107 years. They found that long-livers compared to people aged 85 to 89 years and from 21 to 55 years had higher levels of several types of bacteria, which produce molecules called secondary bile acids. Secondary bile acids are generated by microbes in the colon and, as it is believed to help protect the intestines from pathogens, as well as regulate the immune responses of the body.
One of the molecules is Isoallolca – effectively inhibited the growth of microbial culture with the clostridioides difficile antibiotic bacterium, causing diarrhea and inflammation of the intestines. This bile acid is produced by ODORIBACTEREAAE bacteria with the participation of 5α-reductase enzymes (5ar) and 3β-hydroxysteroiddehydrogenase (3βhsdh). Feeding infected with c.difficile mice with the addition of ISOALLCA also reduced the pathogen level in the body.
Isoallolca killed many other gram-positive (but not gram-negative) pathogens, including Enterococcus Faecium, which indicates that the molecule is able to help the body maintain a fragile balance of microbial communities in a healthy intestine.
gram-positive bacteria is called bacteria that are painted in blue and are not discolored using a gram method and have a thick cell wall. Many pathogenic microorganisms are gram-positive.