Australian biologists from Garvan’s Medical Research Institute along with colleagues from China and Canada found a new way to treat obesity. Scientists found out that when blocking a certain receptor in fatty tissues, the metabolism process changes, and the accumulated fat begins to be more actively spent on the production of energy and thermoregulation. The results of this study were published in the journal Nature Communications.
Scientists have developed an approach in which the drug substance directly affects fat tissue. This method is more efficient and safer than the method that exists at this time aimed at suppressing appetite. It is noted that drugs that reduce the feeling of hunger act on the central nervous system and have many serious side effects that limit their use.
Studying biopsies of adipose tissue of people with obesity, the researchers found that blocking the Y1 neurupptide molecule receptor (NPY), which in the conditions of food deficiency helps to maintain energy, can improve fat metabolism and prevent weight gain.
Scientists conducted a study on mice. They managed to find out that rodents, which were injected with a special substance-antagonist BIBO330 to lock the Y1 receptor, with the same fatty diet began to gain less weight.
“In our study, we found that the mice that were injected by Bibo3304 were scored for about 40 percent less weight than ordinary mice on the same diet. This was due to an increase in body heat and a decrease in adhesion,” explained Dr. Yan-Chuan Shi from Neuroendocrinology Group at the Garvan Institute.
According to him, scientists applied a similar technique to human fat cells and found that they began to switch to heat generation, using the same genes as rodents.
Previously, scientists found a new safe way to lose weight. A group of researchers from Russia and France came to the conclusion that probiotic on the basis of Hafnia Alvei intestinal bacteria can help people with overweight safely relieve extra pounds.